Presymptomatic Transmission of SARS-CoV-2 - Singapore, January 23-March 16, 2020.
Identifieur interne : 000370 ( 2020/Analysis ); précédent : 000369; suivant : 000371Presymptomatic Transmission of SARS-CoV-2 - Singapore, January 23-March 16, 2020.
Auteurs : Wycliffe E. Wei ; Zongbin Li ; Calvin J. Chiew ; Sarah E. Yong ; Matthias P. Toh ; Vernon J. LeeSource :
- MMWR. Morbidity and mortality weekly report [ 1545-861X ] ; 2020.
Descripteurs français
- KwdFr :
- MESH :
- Wicri :
- geographic : Singapour.
English descriptors
- KwdEn :
- MESH :
- geographic , epidemiology : Singapore.
- epidemiology : Coronavirus Infections.
- prevention & control : Coronavirus Infections.
- transmission : Coronavirus Infections.
- Adult, Asymptomatic Diseases, Betacoronavirus, Cluster Analysis, Contact Tracing, Female, Humans, Male, Middle Aged.
Abstract
Presymptomatic transmission of SARS-CoV-2, the virus that causes coronavirus disease 2019 (COVID-19), might pose challenges for disease control. The first case of COVID-19 in Singapore was detected on January 23, 2020, and by March 16, a total of 243 cases had been confirmed, including 157 locally acquired cases. Clinical and epidemiologic findings of all COVID-19 cases in Singapore through March 16 were reviewed to determine whether presymptomatic transmission might have occurred. Presymptomatic transmission was defined as the transmission of SARS-CoV-2 from an infected person (source patient) to a secondary patient before the source patient developed symptoms, as ascertained by exposure and symptom onset dates, with no evidence that the secondary patient had been exposed to anyone else with COVID-19. Seven COVID-19 epidemiologic clusters in which presymptomatic transmission likely occurred were identified, and 10 such cases within these clusters accounted for 6.4% of the 157 locally acquired cases. In the four clusters for which the date of exposure could be determined, presymptomatic transmission occurred 1-3 days before symptom onset in the presymptomatic source patient. To account for the possibility of presymptomatic transmission, officials developing contact tracing protocols should strongly consider including a period before symptom onset. Evidence of presymptomatic transmission of SARS-CoV-2 underscores the critical role social distancing, including avoidance of congregate settings, plays in controlling the COVID-19 pandemic.
DOI: 10.15585/mmwr.mm6914e1
PubMed: 32271722
Affiliations:
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pubmed:32271722Le document en format XML
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Wei</name></author><author><name sortKey="Li, Zongbin" sort="Li, Zongbin" uniqKey="Li Z" first="Zongbin" last="Li">Zongbin Li</name></author><author><name sortKey="Chiew, Calvin J" sort="Chiew, Calvin J" uniqKey="Chiew C" first="Calvin J" last="Chiew">Calvin J. Chiew</name></author><author><name sortKey="Yong, Sarah E" sort="Yong, Sarah E" uniqKey="Yong S" first="Sarah E" last="Yong">Sarah E. Yong</name></author><author><name sortKey="Toh, Matthias P" sort="Toh, Matthias P" uniqKey="Toh M" first="Matthias P" last="Toh">Matthias P. Toh</name></author><author><name sortKey="Lee, Vernon J" sort="Lee, Vernon J" uniqKey="Lee V" first="Vernon J" last="Lee">Vernon J. Lee</name></author></analytic><series><title level="j">MMWR. Morbidity and mortality weekly report</title><idno type="eISSN">1545-861X</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Asymptomatic Diseases</term><term>Betacoronavirus</term><term>Cluster Analysis</term><term>Contact Tracing</term><term>Coronavirus Infections (epidemiology)</term><term>Coronavirus Infections (prevention & control)</term><term>Coronavirus Infections (transmission)</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Singapore (epidemiology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Analyse de regroupements</term><term>Femelle</term><term>Humains</term><term>Infections à coronavirus ()</term><term>Infections à coronavirus (transmission)</term><term>Infections à coronavirus (épidémiologie)</term><term>Maladies asymptomatiques</term><term>Mâle</term><term>Singapour (épidémiologie)</term><term>Traçage des contacts</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Singapore</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" qualifier="transmission" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Infections à coronavirus</term><term>Singapour</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Asymptomatic Diseases</term><term>Betacoronavirus</term><term>Cluster Analysis</term><term>Contact Tracing</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Analyse de regroupements</term><term>Femelle</term><term>Humains</term><term>Infections à coronavirus</term><term>Maladies asymptomatiques</term><term>Mâle</term><term>Traçage des contacts</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Singapour</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Presymptomatic transmission of SARS-CoV-2, the virus that causes coronavirus disease 2019 (COVID-19), might pose challenges for disease control. The first case of COVID-19 in Singapore was detected on January 23, 2020, and by March 16, a total of 243 cases had been confirmed, including 157 locally acquired cases. Clinical and epidemiologic findings of all COVID-19 cases in Singapore through March 16 were reviewed to determine whether presymptomatic transmission might have occurred. Presymptomatic transmission was defined as the transmission of SARS-CoV-2 from an infected person (source patient) to a secondary patient before the source patient developed symptoms, as ascertained by exposure and symptom onset dates, with no evidence that the secondary patient had been exposed to anyone else with COVID-19. Seven COVID-19 epidemiologic clusters in which presymptomatic transmission likely occurred were identified, and 10 such cases within these clusters accounted for 6.4% of the 157 locally acquired cases. In the four clusters for which the date of exposure could be determined, presymptomatic transmission occurred 1-3 days before symptom onset in the presymptomatic source patient. To account for the possibility of presymptomatic transmission, officials developing contact tracing protocols should strongly consider including a period before symptom onset. Evidence of presymptomatic transmission of SARS-CoV-2 underscores the critical role social distancing, including avoidance of congregate settings, plays in controlling the COVID-19 pandemic.</div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Chiew, Calvin J" sort="Chiew, Calvin J" uniqKey="Chiew C" first="Calvin J" last="Chiew">Calvin J. Chiew</name><name sortKey="Lee, Vernon J" sort="Lee, Vernon J" uniqKey="Lee V" first="Vernon J" last="Lee">Vernon J. Lee</name><name sortKey="Li, Zongbin" sort="Li, Zongbin" uniqKey="Li Z" first="Zongbin" last="Li">Zongbin Li</name><name sortKey="Toh, Matthias P" sort="Toh, Matthias P" uniqKey="Toh M" first="Matthias P" last="Toh">Matthias P. Toh</name><name sortKey="Wei, Wycliffe E" sort="Wei, Wycliffe E" uniqKey="Wei W" first="Wycliffe E" last="Wei">Wycliffe E. Wei</name><name sortKey="Yong, Sarah E" sort="Yong, Sarah E" uniqKey="Yong S" first="Sarah E" last="Yong">Sarah E. Yong</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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